Targeted Therapies

Advances in cancer treatment have seen the development of targeted therapies. These are medicines that specifically identify and attack cancer cells without damaging normal cells. They can be an effective form of treatment for many cancers. Zelboraf is a targeted medicine for melanoma.


Zelboraf (vemurafenib) is a medicine that’s used in the treatment of metastatic or secondary melanoma with a certain gene mutation. The melanoma is often known as BRAF-positive melanoma.

Melanomas that are BRAF-positive produce a slightly different BRAF protein and Zelboraf targets this protein to help stop the melanoma cells from growing out of control.

Your doctor can find out if your melanoma has a mutation in the BRAF gene when they do a biopsy or when they remove the melanoma during surgery.

In patients with BRAF-positive metastatic melanoma, Zelboraf has been shown to extend life compared with dacarbazine, a standard chemotherapy.4

Zelboraf is not suitable for everyone. Speak to your doctor about whether Zelboraf is a suitable treatment for you. All medicines can have side effects. Sometimes they are serious, most of the time they are not.

Find out more about Zelboraf, its benefits and its side-effects here.